Anti-Serotonin transporter/SLC6A4 Antibody

Product Name

Anti-Serotonin transporter/SLC6A4 Antibody

View all SLC6A4/5-HTTLPR/Serotonin transporter Antibodies

SKU/Catalog Number

PA1705

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Serotonin transporter/SLC6A4 Antibody catalog # PA1705. Tested in WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Serotonin transporter/SLC6A4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1705)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human SLC6A4.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1705 is reactive to SLC6A4 in Human

Applications

PA1705 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

70 kDa

Calculated molecular weight

70.325kDa

Background of SLC6A4/5-HTTLPR/Serotonin transporter

SLC6A4 (Solute carrier family 6, member 4), also known as SERT (serotonin transporter), is a monoamine transporter protein. The SLC6A4 gene spans 31 kb and contains 14 exons. This protein integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is the target of many antidepressant medications, including those of the SSRI class. It is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human

Validation Images & Assay Conditions

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Anti-SLC6A4 antibody, PA1705, Western blotting
All lanes: Anti SLC6A4 (PA1705) at 0.5ug/ml
Lane 1: U87 Whole Cell Lysate at 40ug
Lane 2: HELA Whole Cell Lysate at 40ug
Lane 3: JURKAT Whole Cell Lysate at 40ug
Predicted bind size: 70KD
Observed bind size: 70KD

Gene/Protein Information For SLC6A4 (Source: Uniprot.org, NCBI)

Alternative Names

5HT transporter; 5-HT Transporter; 5-HTT; 5HTTLPR; 5-HTTLPR; hSERT; HTT5-hydroxytryptamine transporter; Na+/Cl- dependent serotonin transporter; OCD1; Serotonin Transporter 1; SERT; SLC6A4; sodium-dependent serotonin transporter; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4,5-HTTLPR; Solute carrier family 6 member 4,5HTT SLC6A4 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT solute carrier family 6 member 4 sodium-dependent serotonin transporter|5-hydroxytryptamine (serotonin) transporter|5HT transporter|Na+/Cl- dependent serotonin transporter|serotonin transporter 1|solute carrier family 6 (neurotransmitter transporter), member 4|solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

For more info on SLC6A4, check out the SLC6A4 Infographic

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In this infographic, you will see the following information for SLC6A4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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